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Build Your Online Product Catalogs?
| Product Name: |
Buy Agomelatine Powder/nootropic@ycgmp.com
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| Supply Ability: |
500kg/month |
| Related proudcts |
agomelatine, |
| Specifications |
99% |
| Price Term: |
CNF |
| Port of loading: |
HK/Shanghai/Shenzhen |
| Minimum Order |
5g |
| Unit Price: |
$1 |
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Agomelatine
Product Name: Agomelatine
CAS: 138112-76-2
MF: C12H18N4O5S
MW: 330.3601
Purity: 99%
MP: 107-109°C
Grade: Pharmaceutical Grade
Appearance: White Powder
Description
Agomelatine is a melatonergic antidepressant developed by the pharmaceutical co***ny Servier. It is the world's first melatonin receptors MT1 and MT2 agonist class of antidepressants. It applies to the treatment of adult patients with severe depressive. Since that melatonin has high catabolism rate in vivo which mikes its half-life shorter and the selectivity of its receptor located in the SCN poorer, the treatment of circadian rhythms disorders is limited. Indole ring of melatonin is the structure sites of catabolic inactivation.
Agomelatine developed by Servier co***ny is melatonin's naphthalene biological (electronic) isostere analogs. Indole ring is substituted by naphthalene nucleus, which leads it have more metabolic stability than melatonin.
Due to its distinctive mechanism of action, agomelatine is also studied for its effects on sleep regulation. Studies report various improvements in general quality of sleep metrics, as well as specific therapeutic benefits in circadian rhythm disorders.
Mechanism of Action
Agomelatine is melatonin MT1/MT2 receptor agonist and serotonin 2c (5-HT2C) receptor antagonist. It can make depressed patients�biological rhythm disorders return to normal through the synergy between the two and then result in antidepressant efficacy. Its unique mechanism of action has opened up an innovative way to treat depression.
Agomelatine's mechanism of drug action is completely different with antidepressants that are commonly used today, such as selective serotonin reuptake inhibitors (SSRI) and serotonin-norepinephrine reuptake inhibitors (SNRI). The molecular structure of agomelatine directly combines with serotonin 2c (5HT2c) receptor of post-synaptic membrane so as to exert its antidepressant efficacy without increasing serotonin concentration in the synaptic cleft. This unique |
| Company: |
Hangzhou Fuluo Biological Technology Co.,Ltd
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| Contact: |
Ms. Cindy Lee |
| Address: |
4#Xinfeng Road,Hongjie Street,Jianggan District |
| Postcode: |
310017 |
| Tel: |
86-0571-87963072 |
| Fax: |
86-0571-87963072 |
| E-mail: |
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